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2019 CNS Jiyya Drug Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7)

2019 CNS Jiyya Drug Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7)

Meta Description

Gano mahimmancin GM1 a cikin ilimin lissafin ilimin lissafi, da magungunta tsofaffi, da magungunan asibiti a cikin sassan tsakiya da na jiki.

Menene Monosialotrahexosylganglioside Solidum (GM1)

Sugar sodium mai suna Monosialotetrahexosylganglioder wani nerontrophic na gina jiki wanda zance shine GM1.

Gangliosides sun kasance a cikin jinsin ganglio, wanda ya hada da glycosphingolipid tare da sialic acid sauran a kan sarkar sukari. Sarkar polysaccharide da aka haifa yana haɗuwa da cramide ta hanyar haɗin β-glycosidic. Ba wai kawai an kafa su a cikin kwayar cutar ƙwayar cuta ba amma kuma a cikin reticulum endoplasmic.

Kodayake sun hada da 0.1% na nauyin nauyin kwakwalwa, asusun gangliosides kusan kusan 10% na yawan lipids. Suna haifar da bambancin tantanin halitta, apoptosis, neuroprotection, da kuma sakin neurotrophins.

Monosialotetrahexosylganglioside wani fili ne wanda ba shi da ma'ana wanda ya ƙunshi sarkar oligosaccharide da cramada. Wannan kwayar yana nuna nau'o'in hydrophilic da lipophilic. Da yake soluble a cikin ruwa da ƙwayoyin cuta, Monosialotetrahexosylganglioside zai iya sauƙaƙe ta hanyar yaduwar cutar kwakwalwa.

Girasar GM1 mai suna Monosialotetrahexosylgangliother yana taka muhimmiyar rawa a cikin kwakwalwa. Yana nuni da kayyadaddun abubuwa kamar gyaran gyaran lalacewar jiki, gyaran aikin, da kuma sake gyaran bayanan bayan rauni. Saboda wannan dalili, Monosialotetrahexosylganglioder sodium yana da amfani wajen magance mummunan rauni na tsakiya. Wasu daga cikin cututtukan da suka shafi sun hada da cututtuka na cerebrospinal, lalacewar cerebrovascular, da kuma cututtukan cututtukan zuciya. Ƙari daga gare ta an mayar da hankali ne a inda akwai lalata kwayar halitta.

Tarihi na Monosialotetrahexosylganglioside Sodium (GM1)

Nazarin GM1 da rawar da yake ciki neuroprotection Komawa zuwa 1970s. Tun daga wannan lokacin, masana kimiyya sun nuna sha'awa a fili ta hanyar aiwatar da al'adun salula da nazarin dabba. Dukkanin gwaje-gwajen sun mayar da hankali akan tabbatar da muhimmancin GM1 a cikin cututtukan neurodegenerative.

A 1986, ta hanyar TRB SA, an kaddamar da launi mai suna Monosialotetrahexosylganglioder sodium karkashin sunan kasuwanci, GM-1. Ganin cewa sakamakon binciken nazarin dabba ya kasance mai ladabi, likitoci na Amurka sun fara bincike kan rayukan kwayoyin halitta na Monosialotetrahexosylganglioder sodium (GM1). Abubuwan da suka shafi binciken sun kasance marasa lafiya tare da lalacewar CNS saboda rauni na kashin baya, annoba, cutar Parkinson, da kuma Alzheimer.

Tun daga wannan lokacin, jihohin irin su Argentina da Italiya sun amince da maganin lafiyar su don maganin yanayin yanayi.

Labaran ƙwayoyin cuta na Sodium(GM1)Formula Formula

Kayan kwakwalwan ƙwayoyin cuta na Sodium (GM1) (37758-47-7)

Labaran ƙwayoyin cuta na Sodium(GM1) bayani dalla-dalla

CAS No. 37758-47-7
Product Name Sugar Sodium (GM1) Pig Brain
IUPAC Name (2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-[(E,2R,3S)-3-hydroxy-2-(icosanoylamino)icos-4-enoxyl]-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Drug Class Sphingolipids
Ƙaddamarwa Point 207 - 230 ° C
kwayoyin Formula C77H139N3O31
Masanin kwayoyin halitta 1546.841 gmol-1
solubility · Ruwa
· Ƙananan soluble a methanol / chloroform
· Kusan wanda ba shi da tushe a cikin ethanol anhydrous
Appearance White zuwa kashe-fata lyophilized foda
tsarki 98%
Storage Temperatuur -20 ° C
shiryayye Life Shekaru biyu
pH 5.0 to 6.5
nufin abu ɗaya ne GM1 mai sauƙi
·GM1 Ganglioside

Labaran ƙwayoyin cuta na Sodium(GM1) Kayan aikin

Monosialotetrahexosyl ganglioside yana aiki a hanyoyi da yawa. Ƙididdigar ta kasance nau'i na mafi yawan ayyukan ayyukan ilimin lissafi na tsarin mai juyayi.

A cikin tantanin halitta na kwakwalwa, Ayyukan Monosialotetrahexosylganglioside don kula da ma'auni a cikin ciki da waje da jikin jikin mutum. Ba wai kawai yana bunkasa impermeability ba, amma har ma yana fitowa da sodium da katako.

A cikin yanayin saurin ciwo, Monosialotetrahexosylganglioside sodium (GM1) ya zo don kare tsarin tsarin jiki. Yana ƙaddamar da aiki na A2 phospholipase, yana ɗaukar nauyin mahaifa, kuma yana yanke ƙarancin samfurori kyauta.

Brain traumas ya kara yawan aikin kin protein a cikin sel, wanda zai iya zama alhakin apoptosis. GM1 inhibits da juya wannan tsari ta hanyar riƙe da metabolism na sunadarai a cikin cytoplasm da nucleus.

A cikin mitochondrion, Monosialotetrahexosylganglioside yana aiki don daidaita tsarin samar da ATP da ayyukan syshaft. Yana gyara matakan da zai iya lalata ma'aunin sakonnin lantarki da kuma inganta samfurin phosphorylation. A sakamakon haka, aikin kwakwalwa na kwakwalwa yana da lafiya.

Gyaran ƙwayoyin sodium da aka gano da magungunan ƙwayoyin sodium yana ƙarfafa axonal ta hanyar mayar da hankali ga abubuwan bunkasa zuwa ga wasu masu karɓa. Wannan aikin ya sake gyara suturar ƙwayoyin cuta kuma ya inganta yaduwar farfadowa da sauri. Cikin yanayin saurin digiri na biyu, mai yiwuwa saboda lalacewar kwayar cuta na dopamine, Monosialotetrahexosylganglioside zai tabbatar da tasirin kuma inganta rayuwar wadannan kayan aiki.

2019 CNS Jiyya Drug Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7)

Ƙungiyar Solidum (GM1)

Kodayake gangliosides su ne akalla a cikin kwakwalwa, ayyukansu suna da yawa. Wadannan kwayoyin suna da tasiri mai tasiri akan ci gaba, gyarawa, gyare-gyare, da kuma kariya daga zarge-zarge.

GM1 ya ƙi da shekaru. Yara yana hade da yin amfani da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa, ƙananan haske, hadarin ciwon haɗari na haɗari, ko ƙuntatawar ƙwaƙwalwa. Bugu da ƙari, cututtukan da suka tsufa da haihuwa irin su cututtuka na cizon sauro, bugun jini, da kuma lalatawa na iya tashiwa.

Saurin kari na GM1 mai ban mamaki yana taimakawa wajen magance matsalolin tsufa. Wasu daga cikin abubuwan da ke da kyau na Monosialotetrahexosylganglioder sodium (GM1) sun hada da maganin cututtukan Alzheimer, bugun jini, epilepsy, da kuma palsy. Bugu da ƙari, kariyar yana ragewa tsufa inganta ƙwaƙwalwa.

Yin amfani da GM1 a aikace-aikace na asibiti yana da yawa. Alal misali, yawancin kasashen Turai da na Amurka sunyi amfani da allurar sodium don magance cututtukan CNS.

Ƙarin yana ƙarfafa ciwon kwayar tausin jiki, ci gaban kwakwalwar kwakwalwa, da kuma rigakafin cutar kwakwalwa. Mawuyacin haka, wannan kwayar cututtuka tana ɗauke da cututtuka na kwakwalwa, raunin da ya faru da cutar, cututtuka na jini, da cututtukan kwayar cutar ciwon zuciya.

Babban nasara mafi muhimmanci a cikin binciken da aikace-aikacen wannan fili a kan mutane shine gano cewa babu wani mummunar illa ga Monosialotetrahexosyl ganglioside sodium (GM1).

GM1 sakamako ba kawai zato ba ne. A cikin 1976, Ceccarelli ya kafa cewa gangliosides masu tasowa suna haifar da farfadowa ta tsakiya da na jiki da gyaran ƙwayoyin sel. Wannan bincike ya kafa harsashi mai tushe ga malaman da suka nuna sha'awar nazarin aikin GM1 a cikin tsarin kulawa na tsakiya.

Sakamakon gwaje-gwaje na asibitoci sun tabbatar da cewa Monosialotetrahexosylganglioside yana da tasiri mai tasiri akan ci gaban, bambancin, bunkasa, da sake farfadowa da kwayoyin halitta. Bugu da ƙari, nazarin nazarin yadda GM1 ya dace a neuroprotection, neuroplasticity, da kuma watsa synaptic.

A cikin yanayin damuwa, ɗaukar magungunan ƙwayar sodium na Monosialotetrahexosylgangliother zai shafar tsarin da ba da yaduwa a hanyoyi da yawa. Ƙarin kwayoyin ba zai ta'azantar da ƙwayar dendritic na kwayoyin jijiya ba amma kuma kara yawan rayuwarsu. Abu na biyu, kari yana da muhimmiyar rawa a gyara, farfadowa, da kuma dawo da aikin.

Monosialotrahexosyl Ganglioside Solidum (GM1) Hanyar cirewa

Ya zuwa yanzu, Monosialotetrahexosyl ganglioside shine kawai CNS magani wanda yake faruwa a yanayi.

Wannan kwayoyin halitta wani abu ne wanda aka samar da shi a cikin ƙwayar jikin kwayar halitta na mambobi. Dangane da abubuwan da ke tattare da shi a cikin nau'ikan da ke cikin tausayi, masana kimiyya da kuma likitoci sun iya cirewa da amfani da ita a shirye-shiryen maganin maganin maganin magungunan kwayoyin halitta.

Mun cire samfurin Monosialotetrahexosyl daga gwiwar dabbobi. Kodayake zaka iya ware kwayoyin daga sa ko kuma goat, hanya mafi aminci shine ƙwaƙwalwar kwakwalwa. Dalilin shi ne cewa samfurin bijimai ko awaki na Monosialotetrahexosyl zai iya yaduwa da jini irin su mahaukaciyar fata da epilepsy.

Abubuwan da suka dace don kayan haɓaka na Monosialotetrahexosylganglioder sodium (GM1) suna da damar, m, da kuma tattalin arziki. Muna samar muku da mafi kyawun GM1 daga kwakwalwar kwakwalwa, kamar yadda hanyar ba ta kawo cututtuka ga mutane ba.

Don yawan amfanin ƙasa mai yawa, muna amfani da samfurin samfurin chloroform-methanol-ruwa. Bayan haka, zamu gudanar da musayar ra'ayi da rarraba-ɓataccen ɓangaren samfurori. Wannan tsarkakewa yana haifar da kwayoyin homogenous, wanda shine> 98% tsarkake ta hanyar HPLC.

Kammalawa

Ayyukan da ake samu na Monosialotetrahexosyl suna da muhimmanci a aikace-aikace na asibiti. Yana da maganin ƙwayoyi na takardun izini don kula da cututtukan kwayoyin cutar da jiyya na ciwo mai tsanani.

Ko kuna so ku saya GM1 don amfani da ilimin warkewa ko dalilai na bincike, muna bada tabbacin ku samfurin samarda. Mun ƙara girma-samarwa Sugar sodium (GM1) a karkashin ka'idodin kula da inganci.

References

  1. Schneider, JS, Roeltgen, DP, et al. (1998). Cututtukan Parkinson: Ayyukan Kyau tare da GM1 Gliolioside Treatment a cikin Hikimar da aka Gudanar da Cibiyar Wuta.
  2. Bansal, AS, Abdul-Karim, B., Malik, RA, et al. (1994). IgM Ganglioside GM1 Antibodies a cikin marasa lafiya tare da Ciwon Autoimmune ko Neuropathy, da kuma Controls. Clinical Pathology Clinical Pathology.
  3. Mocchetti, I. (2005). Gangliosides mai ban mamaki, Neuronal Filaye da gyare-gyare, da kuma Neurotrophins.
  4. Aureli, M., Mauri, L., Ciampa, MG, Prinetti, A., Toffano, G., et al. (2016). GM1 Ganglioside: Nazarin da suka gabata da Kwarewa na gaba. Magungunan kwayoyin halitta.
  5. Bian, L., Yang, J., da Sun, Y. (2015). Tsarkarwa da Tsarkakewa na Monosialotetrahexosylgangliosides daga Pig Brain by hakar da Liquid Chromatography.